Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Reactive Metabolite induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity* Molecular & Cellular Proteomics Acetaminophen Depletes Glutathione Essential Formulas Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize