Some alternatives to consider before jumping to Tylenol! I want to emphasize that I think the fear surrounding Tylenol can be a little unnecessary and intense. I do believe there are times View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Tylenol's Impact on Glutathione and Liver Damage