In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Glucose 6 Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus Clinics in Perinatology Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency The Medical Biochemistry Page glucose pathways and G6PD Caspershire Meta Rasburicase Induced Hemolytic Anemia Secondary to Undiagnosed G6PD Deficiency Published in Journal of Brown Hospital Medicine