Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Frontiers Manipulations of Glutathione Metabolism Modulate IP3 Mediated Store Operated Ca2+ Entry on Astroglioma Cell Line A New Stage for Seasoned Actors Food Anaphylaxis and the Cysteinyl Leukotrienes New England Journal of Medicine Glutathione pH responsive copper based nanoplatform for amplified chemodynamic therapy through synergistic cycling regeneration of reactive oxygen species and dual glutathione depletion ScienceDirect Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification