Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect New research indicates a correlation between depression and reduced levels of antioxidants in the . Specifically, studies show that individuals with depression often exhibit lower levels of antioxidant enzymes like glutathione and Activity of energy, glutamate, and glutathione metabolism enzymes in blood cells of elderly patients with depression Your Glutathione Index Defines How Your Cells Are Ageing Glutathione: Benefits and Supplements