Labial melanotic macule. B). Increased numbers of me lanocytes along Download Scientific Diagram Pigmented Lesions of the Oral Mucosa Pocket Dentistry Pathology Outlines Melanotic macule Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association